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Frequently Asked Questions

How long after infection will HerpeSelect detect IgG antibodies?
HerpeSelect can detect HSV IgG antibodies as quickly as 3 weeks after the onset of a patient's symptoms4. It is important to note that each individual may seroconvert at different rate leading to earlier or delayed detection. Some patients do not seroconvert for 6 months or longer.

Is there a need for HSV IgM testing?
The presence of IgM antibodies in herpes simplex virus (HSV) infections is difficult to interpret. The presence of IgM may indicate a true primary infection. However, the test has low sensitivity, high incidence of cross-reactivity and low negative predictive value (NPV). Additionally, the presence of IgM may be due to the reactivation of a latent HSV-1 or HSV-2 infection. For these reasons, IgM testing is not recommended, but may offer information about a particular patient’s antibody response.

What confirmatory testing is necessary for HerpeSelect type specific assays?
As with other serological tests, false results may occur. Repeat testing or testing with a different device may be indicated in some circumstances, for example, patients with a low likelihood of HSV infection. All results must be correlated with clinical history, epidemiological data, and other data available to the attending physician in evaluating the patient.

Is HerpeSelect reimbursed by payers?
CPT codes for herpes type-specific serology have been established. Please check with your local Medicare branch or private payers for exact reimbursement amounts.

Medicare Part B
HSV-1 CPT Code 86695*
HSV-2 CPT Code 86696*

*The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

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